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Bioreactor-fermentor sél CGMP

5L 7L 10L 30L 40L bioreactor sél (kaca)

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  • Kalebihan & Kauntungan
  • spésifikasi
  • aplikasi
  • panalungtikan
gambaran

jumlah

barang

gambaran

2

Sistem bejana

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume) and 7 liter (4-5 liters working volume) and 10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes : Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

Agitation

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

Panyebutan

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

liang hawa

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

panyilidikan

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

Sistem Sampling

Autoclavable sampling system

inoculum

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

catu daya

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

suhu Control

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

Speed Setting

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

takeran

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:mesin sealing system at the top of the fermenter; high-powered stirring oar, antifoam oar; AC mesin listrik: infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

kadali hawa

Interlayer electric calefaction, auto-control

2

kontrol Airflow

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger - One number sparger.

2

Kontrol antifoam

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Feeding control

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively.

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

sistim kontrol

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Parangkat Lunak: Siemens S7 + FORCE CONTORL

Ngumpulkeun data sareng modul kontrol: Siemens S200 PLC controller sareng kumpulan data sareng modul kontrol

1. pangawasan
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

2. Fungsi pangukuran: tiasa nyoco, musuh gelembung, sapertos ngukur pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

4. Ngolah Data
1) pikeun nunjukkeun yén sakabéh parameter analisis kurva tren
2) pikeun nyimpen, ningalikeun, nganalisa sadayana parameter kurva bersejarah
3) tiasa nampilkeun sadayana parameter laporan tumpak
4) nyalin data langsung sareng USB

5) format gudang data cocog sareng EXCEL, platform EXCEL tiasa diungkulan
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Tiasa parameter kontrol prosés, unggal parameter tiasa ngagaduhan 10 blok tiasa diatur
7. Pintonan waktos unggal interval rékaman rékaman tiasa disaluyukeun
8. Dua parameter tiasa dilaksanakeun kalayan setélan layar sareng kalibrasi

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. Masing-masing parameter transmisi mangrupikeun modul anu mandiri, tanpa silih ganggu, pikeun gampang diropea
11.PH, DO sareng parameter sanés kontrol sareng kontrol anu aya hubunganana tiasa disaluyukeun

Kauntungan kalapa

parameter teknis:

teu

Parameter

guideline

Fungsi ngolah data Controller

1

PH

Munculna rentang: 0.00 ~ 14.00 ± 0.01

Auto-control range:2.00 ~ 12.00 ± 0.05

Fermentation kontrol prosés (According to the fermentation time, auto- control pH fluent, at least10 parts)

pH value historical and trend curve analysis

Analisis kurva dosis asam, alkali

Analisis bentuk laporan kelompok

Asam, total rékaman dosis alkali

Tetep sareng pangiriman data

2

DO

0-150±3%,mintonkeun precision: 0.1%

It can be controlled by rev and feeding.

Fermentation kontrol prosés (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Analisis bentuk laporan kelompok

Tetep sareng pangiriman data

3

Antifoam

otomatis PID control and alarm

Fermentation kontrol prosés (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Catetan kaayaan kasalahan busa

antifoam total catetan dosis

Analisis bentuk laporan kelompok

Tetep sareng pangiriman data

4

blk

otomatis enactment jeung kontrol(50~300rpm±5‰)

Fermentation kontrol prosés (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Analisis bentuk laporan kelompok

Tetep sareng pangiriman data

5

suhu

Suhu cai tiis: +5-80± 0.2 ℃

Fermentation kontrol prosés (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Analisis bentuk laporan kelompok

Tetep sareng pangiriman data

6

dahar

PID automatic enactment jeung kontrol

Fermentation kontrol prosés (According to the fermentation time, auto- control feeding fluent, at least10 parts)

Feeding value historical and trend curve analysis

Dahar rékaman dosis total

Analisis bentuk laporan kelompok

Tetep sareng pangiriman data

7

tekenan

Kontrol manual, tampilan instrumen

8

Fluks hawa

mass flowmeter control gas flow


spésifikasi

System main parts

barang

barang

gambaran

Quant.

sumber

1

tank

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom heating blanket.

1

Bailun

2

Machinery seal

John Crane

1

karajaan Inggris

3

Stirring motor

Mechanical stirring: TECO

1

TECO

4

Gupernur

Mechanical stirring: TECO

1

TECO

5

Silicon pipe

panjang

10M

Baoding

6

Sistem PLC

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailun

7

Aliran massa termal

10-100L/H Vogtlin

1

Swiss

8

Air intake filter

Sartorius, 0.2μm φ50

1

Sartorius

9

Saringan napas

Sartorius φ37

1

Sartorius

10

Feeding peristaltic pump

BL-0~32 ml\min

1

panjang

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

panjang

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

panjang

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

panjang

14

PH electrode

Switzerland imported 225

1

Swiss

15

PH cable

Switzerland imported 3m

1

Swiss

16

DO electrode

Switzerland imported 220

1

Swiss

17

DO cable

Switzerland imported 3m

1

Swiss

18

Temperature electrode

PT100

1

Jepang

19

klep éléktromagnétik

DN8-UNIT

1

Taiwan

20

batur

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

Shanghai

aplikasi
vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Biopharmaceutical bioreactor
apotik
farmasi
ubar
Antibodi monoklonal
antibiotik
antibiotik
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
paksin
Biopharmaceutical
sél manusa
plant cell culture
Taros Kami
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