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Cell bioreactors-Fermentors CGMP

5L 7L 10L 30L 40L cell bioreactor (girazi)

  • tsananguro
  • Makwikwi & Anobatsira
  • Magadzirirwo
  • Applications
  • muvhunzo
tsananguro

nhamba

chinhu

tsananguro

2

Vessel system

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume) and 7 liter (4-5 liters working volume) and 10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes : Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

Kushungurudzika

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

Aeration

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

kufefetedza

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

Zvimwe

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

Sampling System

Autoclavable sampling system

inoculum

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

Power zvitengeswa

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

Temperature Control

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

Speed Setting

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

Dosage

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:Mechanical sealing system at the top of the fermenter; high-powered stirring oar, antifoam oar; AC muchina wemagetsi: infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

Kuderedza kupisa

Interlayer electric calefaction, auto-control

2

wokufema kuzvidzora

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger - One number sparger.

2

Antifoam kutonga

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Feeding control

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively.

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

Control system

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Software: Motorola S7 + YOKUFUNGA MAHARA

Data collection and control module: Siemens S200 PLC controller and data collection and control module

1. dzora
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

2. Measurement function: can feeding, bubble enemy, such as measurement of pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

4. Data Processing
1) kuratidza kuti iyo yese parameter yeiyo maitiro Curve kuongororwa
2) kuchengetedza, kuratidza, ongorora ese epamidhi curve paramita
3) inogona kuratidza iyo yese paramita ye batch mushumo
4) kopa iyo data zvakananga ne USB

5) data storage format is compatible with EXCEL, EXCEL platform can be to deal with
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Can the process control parameters, each parameter can have 10 block can be set
7. Nguva yekuratidzwa kweparamende yega yega yekurebesa nguva inogona kugadziriswa
8. Maviri ma paramitha anogona kuitiswa necreen screen uye calibration

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. Each parameter of the transmission are independent modules, without disturbing each other, for easy maintenance
11.PH, DO and other parameters of control and associated controls can be adjusted

Kukwikwidza Kunobatsira

Technical parameter:

Aihwa

Parameter

Guideline

Anodzora data processing basa

1

PH

Kuratidza huwandu: 0.00 ~ 14.00 ± 0.01

Auto-control range:2.00 ~ 12.00 ± 0.05

Fermentation process control (According to the fermentation time, auto- control pH fluent, at least10 parts)

pH value historical and trend curve analysis

Acid, alkali dosage curve kuongororwa

Batch ripoti fomu yekuongororwa

Acid, alkali yakazara dosage rekodhi

Chengetedza uye ununure data

2

DO

0-150±3%,Displaying precision: 0.1

It can be controlled by rev and feeding.

Fermentation process control (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Batch ripoti fomu yekuongororwa

Chengetedza uye ununure data

3

Antifoam

otomatiki PID control and alarm

Fermentation process control (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Foam kukanganisa mamiriro rekodhi

antifoam yakazara dosage rekodhi

Batch ripoti fomu yekuongororwa

Chengetedza uye ununure data

4

Zvak

otomatiki enactment uye kudzora(50~300rpm±5‰)

Fermentation process control (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Batch ripoti fomu yekuongororwa

Chengetedza uye ununure data

5

tembiricha

Kupisa kwemvura inotonhorera: +5-80± 0.2 ℃

Fermentation process control (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Batch ripoti fomu yekuongororwa

Chengetedza uye ununure data

6

Kudyisa

PID automatic enactment uye kudzora

Fermentation process control (According to the fermentation time, auto- control feeding fluent, at least10 parts)

Feeding value historical and trend curve analysis

Kudyisa yakazara dosage rekodhi

Batch ripoti fomu yekuongororwa

Chengetedza uye ununure data

7

Pressure

Manual kudzora, chiridzwa kuratidza

8

Mhepo flux

mass flowmeter control gas flow


Magadzirirwo

System main parts

chinhu

chigadzirwa

tsananguro

Quant.

mabviro

1

tangi

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom heating blanket.

1

Bailun

2

Machinery seal

John Crane

1

United Kingdom

3

Inofambisa mota

Mechanical stirring: TECO

1

TECO

4

Speed governor

Mechanical stirring: TECO

1

TECO

5

Silicon pipe

Lange

10M

Baoding

6

PLC system

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailun

7

Thermal yakawanda inoyerera

10-100L/H Vogtlin

1

Siwizarendi

8

Air intake filter

Sartorius, 0.2μm φ50

1

Sartorius

9

Kufema kufema

Sartorius φ37

1

Sartorius

10

Feeding peristaltic pump

BL-0~32 ml\min

1

Lange

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

Lange

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

Lange

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

Lange

14

PH electrode

Switzerland imported 225

1

Siwizarendi

15

PH cable

Switzerland imported 3m

1

Siwizarendi

16

DO electrode

Switzerland imported 220

1

Siwizarendi

17

DO cable

Switzerland imported 3m

1

Siwizarendi

18

Temperature electrode

PT100

1

Japani

19

Electromagnetic valve

DN8-UNIT

1

Taiwan

20

vamwe

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

Shanghai

Applications
vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Biopharmaceutical bioreactor
chitoro chemishonga
Pharmaceuticals
mushonga
Monoclonal antibodies
Antibiotics
antibiotic
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
mushonga
Biopharmaceutical
masero emunhu
plant cell culture
Taura nesu
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