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Клеточные биореакторы-ферментеры CGMP

5л 7л 10л 30л 40л клеточный биореактор (стекло)

  • Описание
  • Конкурентное преимущество
  • Характеристики
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Описание

номер

Наименования

Описание

2

Vessel system

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume)    and  7 liter (4-5 liters working volume)  and  10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes :   Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

Агитация

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

проветривание

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

Вентиляция

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

Зонды

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

Система отбора проб

Autoclavable sampling system

Inoculum

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

Источник питания

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

Контроль температуры

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

Настройка скорости

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

дозировка

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:Механические sealing system at the top of the fermenter; мощный stirring oar, antifoam oar; AC электрическая машина:  infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

Контроль температуры

Interlayer electric calefaction, auto-control

2

Airflow control

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger One number sparger.

2

Противопенный контроль

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Feeding control

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively. 

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

Система контроля

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Software: Siemens S7+  FORCE  CONTORL

Модуль сбора и управления данными: контроллер ПЛК Siemens S200 и модуль сбора и управления данных

1. Контроль
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

 

2. Функция измерения: кормление банок, враг пузыря, например, измерение pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

Обработка данных 4.
1) показать, что все параметры анализа кривой тренда
2) хранить, отображать, анализировать все параметры исторической кривой
3) может отображать все параметры пакетного отчета
4) скопируйте данные напрямую с USB

 

5) формат хранения данных совместим с EXCEL, платформа EXCEL может иметь дело с
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Могут быть установлены параметры управления процессом, каждый параметр может иметь 10 блоков.
7. Отображение времени каждого интервала записи параметра можно отрегулировать.
8. Два параметра могут быть выполнены с настройками экрана и калибровкой.

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. Каждый параметр трансмиссии представляет собой независимые модули, не мешая друг другу, для простоты обслуживания.
11.PH, DO и другие параметры управления и связанные с ними элементы управления могут быть отрегулированы

Конкурентное преимущество

Technical parameter:

 

Нет 

Parameter 

 

Руководство 

 

Controller data processing function 

1

PH

Displaying range: 0.00 ~ 14.00 ± 0.01 

Auto-control range:2.00 ~ 12.00 ± 0.05

Fermentation управления технологическими процессами (According to the fermentation time, auto- control pH fluent, at least10 parts) 

pH value historical and trend curve analysis

Acid, alkali dosage curve analysis

Batch report form analysis

Acid, alkali total dosage record

Keep and deliver data

2

 

DO

 

0-150±3%,Отображение precision: 0.1%

It can be controlled by rev and feeding. 

Fermentation управления технологическими процессами (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

3

 

 

противовспениватель

 

Автоматически PID control and alarm 

Fermentation управления технологическими процессами (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Foam error state record 

antifoam total dosage record

Batch report form analysis

Keep and deliver data

4

 

 

оборот

Автоматически принятие И контроль(50~300rpm±5‰)

Fermentation управления технологическими процессами (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

5

 

Перемена температур

Temperature of cooling water: +5-80± 0.2 ℃

Fermentation управления технологическими процессами (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

6

 

 

продукты

PID automatic принятие И контроль 

Fermentation управления технологическими процессами (According to the fermentation time, auto- control feeding fluent, at least10 parts) 

Feeding value historical and trend curve analysis

Feeding total dosage record

Batch report form analysis

Keep and deliver data

7

 

 

Давление

Manual control, instrument display 

 

8

 

 

Air flux

 mass flowmeter  control gas flow 

 


Характеристики

System  main parts

Наименования

Продукт

Описание

Quant.

Источник

1

нефтебаза"

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom одеяло отопления.

1

Bailun

2

Машинное уплотнение

Джон Крейн

1

United Kingdom

3

Двигатель перемешивания

Mechanical stirring: TECO     

1

ТЕКО

4

Регулятор скорости

Mechanical stirring: TECO     

1

ТЕКО

5

Silicon pipe

Ланге

10M

Баодин

6

Система ПЛК

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailun

7

Тепловой массовый расходомер

10-100L/H    Vogtlin

1

Швейцария

8

Air intake filter

Sartorius, 0.2μm φ50

1

портняжная мышца

9

Дыхательный фильтр

портняжная мышца φ37

1

портняжная мышца

10

Feeding peristaltic pump

BL-0~32 ml\min

1

Ланге

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

Ланге

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

Ланге

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

Ланге

14

PH  electrode

Switzerland imported 225

1

Швейцария

15

PH cable

Switzerland imported 3m

1

Швейцария

16

DO  electrode

Switzerland imported 220

1

Швейцария

17

DO cable

Switzerland imported 3m

1

Швейцария

18

Temperature  electrode

PT100

1

Япония

19

Электромагнитный клапан

DN8-UNIT

1

Тайвань

20

Другое

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

Шанхай

Применение
vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Biopharmaceutical bioreactor
аптека 
фармацевтическая
медицина
Monoclonal antibodies
Антибиотики
антибиотик
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
Вакцина
биофармацевтических
human cells 
plant cell culture 
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