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Ląstelių bioreaktoriai-fermentatoriai CGMP

5L 7L 10L 30L 40L ląstelių bioreaktorius (stiklinis)

  • aprašymas
  • Konkurencinis pranašumas
  • specifikacija
  • Programos
  • tyrimas
aprašymas

skaičius

Punktas

aprašymas

2

Laivų sistema

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume) and 7 liter (4-5 liters working volume) and 10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes : Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

Agitacija

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

vėdinimas

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

Vėdinimas

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

zondai

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

Sampling System

Autoclavable sampling system

užkratas

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

Elektros energijos tiekimas

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

Šiluma

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

Speed Setting

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

Dozė

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:Mechaninis sealing system at the top of the fermenter; high-powered stirring oar, antifoam oar; AC elektros mašina: infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

Temperatūros valdymas

Interlayer electric calefaction, auto-control

2

oro srauto kontrolė

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger - One number sparger.

2

Apsauga nuo putų

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Feeding control

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively.

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

Valdymo sistema

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Programinė įranga: Siemens S7 + FORCE CONTORL

Duomenų rinkimo ir valdymo modulis: „Siemens S200 PLC“ valdiklis ir duomenų rinkimo bei valdymo modulis

1. Kontrolė
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

2. Matavimo funkcija: gali maitinti, pūsti priešą, pavyzdžiui, matuoti pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

4. Duomenų apdorojimas
1) parodyti, kad visi tendencijos kreivės analizės parametrai
2) saugoti, rodyti, analizuoti visus istorinius kreivės parametrus
3) gali parodyti visus siuntos ataskaitos parametrus
4) nukopijuokite duomenis tiesiai per USB

5) duomenų saugojimo formatas yra suderinamas su EXCEL, su EXCEL platforma gali susidurti
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Ar proceso valdymo parametrai gali būti nustatyti, kiekvienas parametras gali turėti 10 blokų
7. Galima koreguoti kiekvieno parametro įrašymo intervalo rodymą
8. Ekrano nustatymais ir kalibravimu galima atlikti du parametrus

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. Kiekvienas transmisijos parametras yra nepriklausomi moduliai, netrukdydami vienas kitam, kad juos būtų lengva prižiūrėti
11.PH, DO ir kiti valdymo bei susijusių valdiklių parametrai gali būti sureguliuoti

Konkurencinis pranašumas

Techninis parametras:

Ne

Parameter

Gaires

Valdiklio duomenų apdorojimo funkcija

1

PH

Rodomas diapazonas: 0.00 ~ 14.00 ± 0.01

Auto-control range:2.00 ~ 12.00 ± 0.05

Fermentation procesų valdymo (According to the fermentation time, auto- control pH fluent, at least10 parts)

pH value historical and trend curve analysis

Rūgščių ir šarmų dozių kreivės analizė

Partijos ataskaitos formos analizė

Rūgščių, šarmų bendros dozės įrašas

Saugokite ir pateikite duomenis

2

DO

0-150±3%,Parodyta precision: 0.1%

It can be controlled by rev and feeding.

Fermentation procesų valdymo (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Partijos ataskaitos formos analizė

Saugokite ir pateikite duomenis

3

Putplasčio prevencija

Automatinis PID control and alarm

Fermentation procesų valdymo (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Putų klaidų būsenos įrašas

kovos su putplasčiu dozės įrašas

Partijos ataskaitos formos analizė

Saugokite ir pateikite duomenis

4

rev

Automatinis įvaikinimas ir kontrolė(50~300rpm±5‰)

Fermentation procesų valdymo (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Partijos ataskaitos formos analizė

Saugokite ir pateikite duomenis

5

temperatūra

Aušinamojo vandens temperatūra: +5-80± 0.2 ℃

Fermentation procesų valdymo (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Partijos ataskaitos formos analizė

Saugokite ir pateikite duomenis

6

Šėrimas

PID automatic įvaikinimas ir kontrolė

Fermentation procesų valdymo (According to the fermentation time, auto- control feeding fluent, at least10 parts)

Feeding value historical and trend curve analysis

Šėrimo bendros dozės įrašas

Partijos ataskaitos formos analizė

Saugokite ir pateikite duomenis

7

Slėgis

Rankinis valdymas, prietaisų rodymas

8

Oro srautas

mass flowmeter control gas flow


specifikacija

System main parts

Punktas

produktas

aprašymas

Quant.

Šaltinis

1

Bakas

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom šildymo antklodė.

1

Bailunas

2

Machinery seal

Johnas Crane'as

1

Didžioji Britanija

3

Stirring motor

Mechanical stirring: TECO

1

TECO

4

Greičio viršininkas

Mechanical stirring: TECO

1

TECO

5

Silicon pipe

Lange

10M

Baodingas

6

PLC system

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailunas

7

Terminis masės srauto matuoklis

10-100L/H Vogtlin

1

Šveicarija

8

Air intake filter

Sartorius, 0.2μm φ50

1

Sartorius

9

Kvėpavimo filtras

Sartorius φ37

1

Sartorius

10

Feeding peristaltic pump

BL-0~32 ml\min

1

Lange

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

Lange

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

Lange

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

Lange

14

PH electrode

Switzerland imported 225

1

Šveicarija

15

PH cable

Switzerland imported 3m

1

Šveicarija

16

DO electrode

Switzerland imported 220

1

Šveicarija

17

DO cable

Switzerland imported 3m

1

Šveicarija

18

Temperature electrode

PT100

1

Japonija

19

Elektromagnetinis vožtuvas

DN8-UNIT

1

Taivanas

20

kiti

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

Šanchajus

Programos
vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Biofarmacinis bioreaktorius
vaistinė
vaistai
medicina
Monokloniniai antikūnai
Antibiotikai
antibiotikas
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
Vakcina
Biofarmacinis preparatas
žmogaus ląsteles
plant cell culture
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