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ʻO nā bioreactors pūnaewele-fermentors CGMP

5L 7L 10L 30L 40L cell bioreactor (aniani)

  • Description
  • Hoʻok & lanakila
  • hoakaka
  • noi
  • ninau
Description

helu

'ikamu

Description

2

ʻŌnaehana ʻōnaehana

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume) and 7 liter (4-5 liters working volume) and 10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes : Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

Hoʻomaha

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

Aaan

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

Ventilation

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

Nāhea

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

Sampling System

Autoclavable sampling system

inoculum

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

Lako ikehu

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

mahana Na Makuahine

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

Speed Setting

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

Hoʻoponopono

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:Ke kuhikuhi sealing system at the top of the fermenter; high-powered stirring oar, antifoam oar; AC mīkini mīkini: infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

ʻO ke kaohi o ka pale

Interlayer electric calefaction, auto-control

2

Airflow hoʻoholo

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger - One number sparger.

2

ʻO ka mana Antifoam

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Feeding control

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively.

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

ʻO ke kaʻina hana

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Mea Hana Pūnaewele: Siemens S7 + FORCE CONTORL

Ka ʻikepili a me ka hoʻokolohua module: Siemens S200 PLC kaohi a me ka hōʻiliʻili a me ke kāʻei hoʻopaʻa

1. Na Makuahine
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

2. Ka hana hana: hiki ke hānai, hoʻoheheʻe i nā ʻenemi, e like me ke ana ʻana o ka pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

4. Ka ʻikepili ʻana
1) e hōʻike i nā helu āpau o ke kaila huli o ka huli ʻana
2) e mālama, hōʻike, hoʻākāka i nā ʻāpana āwau mōʻaukala kahiko
3) hiki ke hōʻike i nā kaha āpau o ka hōʻike batch
4) kope kope i ka ʻikepili me ka USB

5) ʻoi ka hoʻonohonoho o ka 'ikepili helu me ka EXCEL, hiki i ka platform EXCEL ke alo me ke alo
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Hiki i ke kaʻina hoʻomohala i nā ʻōnaehana, hiki i kēlā me kēia pākahi ke loaʻa 10 poloka
7. Hiki ke hoʻoponopono ʻia ka hōʻike ʻana o kēlā me kēia manawa hoʻopaʻa leo manawa
8. Hiki ke lawe ʻia ʻelua mau ʻāpana me nā hoʻonohonoho o ka pā a me ka calibration

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. ʻO kēlā me kēia hiʻohiʻona o ka hoʻoiho he mau modules kūʻokoʻa, me ka hoʻoluhi ʻole ʻana i kēlā me kēia, no ka mālama maʻalahi
11.PH, DO a me nā kaha ʻē aʻe o ka kaohi a me nā mana e pili ana i hiki ke hoʻoponopono ʻia

ʻO ka pono kūpono

Paenaʻikepili:

ʻAʻole

Parameter

Kuhi Kuhi

Pūnaehana hoʻoili ʻia ka ʻike Controller

1

PH

E hōʻike ana i nā pae: 0.00 ~ 14.00 ± 0.01

Auto-control range:2.00 ~ 12.00 ± 0.05

Fermentation process control (According to the fermentation time, auto- control pH fluent, at least10 parts)

pH value historical and trend curve analysis

Ka helu, hoʻonaninani kalepa pālua

Ka loiloi palapala kikoo

Acid, alkali papa helu papa helu

Mālama a hoʻolilo i ka ʻikepili

2

DO

0-150±3%,Hōʻike precision: 0.1%

It can be controlled by rev and feeding.

Fermentation process control (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Ka loiloi palapala kikoo

Mālama a hoʻolilo i ka ʻikepili

3

Antifoam

akomi PID control and alarm

Fermentation process control (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Hoʻoilina hōʻike i ka hōʻike

antifoam total dosage record

Ka loiloi palapala kikoo

Mālama a hoʻolilo i ka ʻikepili

4

Hōʻike

akomi enactment a me ka mana(50~300rpm±5‰)

Fermentation process control (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Ka loiloi palapala kikoo

Mālama a hoʻolilo i ka ʻikepili

5

mahana

ʻO ka wai wela o ka wai: +5-80± 0.2 ℃

Fermentation process control (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Ka loiloi palapala kikoo

Mālama a hoʻolilo i ka ʻikepili

6

e ai ana

PID automatic enactment a me ka mana

Fermentation process control (According to the fermentation time, auto- control feeding fluent, at least10 parts)

Feeding value historical and trend curve analysis

Ka hoʻolilo ʻana i ka hōʻike dosage uku

Ka loiloi palapala kikoo

Mālama a hoʻolilo i ka ʻikepili

7

puʻuwai

ʻAno hoʻomalu, hōʻikeʻike

8

Ka maʻi ʻeha

mass flowmeter control gas flow


hoakaka

System main parts

'ikamu

Product

Description

Quant.

kahi

1

pahu

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom heating blanket.

1

Bailun

2

Machinery seal

John Crane

1

Aupuni Mōʻī Hui Pū ʻia

3

Stirring motor

Mechanical stirring: TECO

1

TECO

4

Speed governor

Mechanical stirring: TECO

1

TECO

5

Silicon pipe

Lange

10M

Baoding

6

PLC system

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailun

7

Holoi ʻōlia ʻōmole

10-100L/H Vogtlin

1

Kuikilana

8

Air intake filter

Sartorius, 0.2μm φ50

1

ʻO Soriro

9

ʻO ka kānana manawa

ʻO Soriro φ37

1

ʻO Soriro

10

Feeding peristaltic pump

BL-0~32 ml\min

1

Lange

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

Lange

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

Lange

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

Lange

14

PH electrode

Switzerland imported 225

1

Kuikilana

15

PH cable

Switzerland imported 3m

1

Kuikilana

16

DO electrode

Switzerland imported 220

1

Kuikilana

17

DO cable

Switzerland imported 3m

1

Kuikilana

18

Temperature electrode

PT100

1

Iapana

19

ʻO ka valve electromagnetic

DN8-UNIT

1

Taiwan

20

kekahi

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

Shanghai

noi
vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Bioreactor biopharmaceutical
Hale kū'ai
nā lāʻauʻona
lapaau
Nā antibodie Monoclonal
Antibiotics
huakikī
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
laʻau koʻokoʻo
Biopharmaceutical
nā pūnaehana kanaka
plant cell culture
Kāhea iā mā˚ou
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