Knikbioreactors
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بیوراکتور سلولز-فرمنتر CGMP

بیوراکتور سلولی 5 لیتر 7 لیتر 10 لیتر 30 لیتر 40 لیتری (شیشه ای)

  • توضیحات:
  • مزیت رقابتی
  • مشخصات
  • اپلیکیشن‌ها
  • پرس و جو
توضیحات:

عدد

مورد

توضیحات:

2

Vessel system

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume)    and  7 liter (4-5 liters working volume)  and  10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes :   Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

تحریک

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

هوادهی

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

تهویه

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

پروب ها

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

سیستم نمونه برداری

Autoclavable sampling system

Inoculum

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

منبع تغذیه

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

کنترل دما

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

تنظیم سرعت

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

مقدار مصرف

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:مکانیکی سیستم آب بندی at the top of the fermenter; high-powered stirring oar, antifoam oar; AC ماشین الکتریکی:  infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

کنترل دما

Interlayer electric calefaction, auto-control

2

Airflow control

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger - One number sparger.

2

کنترل ضد نفخ

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Feeding control

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively. 

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

سیستم کنترل

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Software: Siemens S7+  FORCE  CONTORL

Data collection and control module: Siemens S200 PLC controller and data collection and control module

1. کنترل
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

 

2. Measurement function: can feeding, bubble enemy, such as measurement of pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

4 پردازش داده ها
1) to show that all the parameters of the trend curve analysis
2) to store, display, analyze all the historical curve parameters
3) can display all the parameters of the batch report
4) copy the data directly with the USB

 

5) data storage format is compatible with EXCEL, EXCEL platform can be to deal with
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Can the process control parameters, each parameter can have 10 block can be set
7. Time display of each parameter recording interval can be adjusted
8. Two parameters can be carried out with the screen settings and calibration

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. Each parameter of the transmission are independent modules, without disturbing each other, for easy maintenance
11.PH, DO and other parameters of control and associated controls can be adjusted

مزیت رقابتی

Technical parameter:

 

نه 

Parameter 

 

راهنما 

 

Controller data processing function 

1

PH

Displaying range: 0.00 ~ 14.00 0.01 

Auto-control range:2.00 ~ 12.00 0.05

Fermentation کنترل فرایندها (According to the fermentation time, auto- control pH fluent, at least10 parts) 

pH value historical and trend curve analysis

Acid, alkali dosage curve analysis

Batch report form analysis

Acid, alkali total dosage record

Keep and deliver data

2

 

DO

 

0-150±3%,نمایش precision: 0.1٪

It can be controlled by rev and feeding. 

Fermentation کنترل فرایندها (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

3

 

 

ضد کف

 

اتوماتیک PID control and alarm 

Fermentation کنترل فرایندها (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Foam error state record 

antifoam total dosage record

Batch report form analysis

Keep and deliver data

4

 

 

برگرد

اتوماتیک enactment و کنترل(50~300rpm±5‰)

Fermentation کنترل فرایندها (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

5

 

درجه حرارت

Temperature of cooling water: +5-80± 0.2 ℃

Fermentation کنترل فرایندها (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

6

 

 

تغذیه

PID automatic enactment و کنترل 

Fermentation کنترل فرایندها (According to the fermentation time, auto- control feeding fluent, at least10 parts) 

Feeding value historical and trend curve analysis

Feeding total dosage record

Batch report form analysis

Keep and deliver data

7

 

 

فشار

Manual control, instrument display 

 

8

 

 

Air flux

 mass flowmeter  control gas flow 

 


مشخصات

System  main parts

مورد

محصول

توضیحات:

Quant.

منبع

1

مخزن

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom پتو گرمایش.

1

Bailun

2

مهر و موم ماشین آلات

John Crane

1

انگلستان

3

موتور همزن

Mechanical stirring: TECO     

1

TECO

4

فرماندار سرعت

Mechanical stirring: TECO     

1

TECO

5

Silicon pipe

لانگه

10M

بائودینگ

6

سیستم PLC

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailun

7

جریان سنج جرمی حرارتی

10-100L/H    Vogtlin

1

سوئیس

8

Air intake filter

Sartorius, 0.2μm φ50

1

سارتوریوس

9

فیلتر تنفس

سارتوریوس φ37

1

سارتوریوس

10

Feeding peristaltic pump

BL-0~32 ml\min

1

لانگه

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

لانگه

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

لانگه

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

لانگه

14

PH  electrode

Switzerland imported 225

1

سوئیس

15

PH cable

Switzerland imported 3m

1

سوئیس

16

DO  electrode

Switzerland imported 220

1

سوئیس

17

DO cable

Switzerland imported 3m

1

سوئیس

18

Temperature  electrode

PT100

1

ژاپن

19

دریچه الکترومغناطیسی

DN8-UNIT

1

تایوان

20

دیگران

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

ربودن

اپلیکیشن‌ها
vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Biopharmaceutical bioreactor
داروخانه 
دارو
پزشکی
Monoclonal antibodies
آنتی بیوتیک ها
آنتی بیوتیک
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
واکسن
بیو دارویی
human cells 
plant cell culture 
تماس با ما

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