Knikbioreaktory
jazyk
Buněčné bioreaktory-fermentory CGMP

5L 7L 10L 30L 40L buněčný bioreaktor (sklo)

  • Popis
  • Konkurenceschopnost a výhoda
  • Specifikace
  • Aplikace
  • dotaz
Popis

číslo

Položka

Popis

2

Systém plavidel

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume) and 7 liter (4-5 liters working volume) and 10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes : Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

Míchání

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

Provzdušňování

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

Větrání

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

Sondy

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

Sampling System

Autoclavable sampling system

očkovací

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

napájení

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

Řízení teploty

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

Speed Setting

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

Dávkování

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:mechanický sealing system at the top of the fermenter; high-powered stirring oar, antifoam oar; AC electrical machine: infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

Řízení teploty

Interlayer electric calefaction, auto-control

2

proudění vzduchu

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger - One number sparger.

2

Odstraňování pěny

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Feeding control

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively.

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

Kontrolní systém

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Software: Siemens S7 + FORCE CONTORL

Data collection and control module: Siemens S200 PLC controller and data collection and control module

1 Kontrola
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

2. Measurement function: can feeding, bubble enemy, such as measurement of pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

4. Zpracování dat
1) ukázat, že všechny parametry analýzy trendové křivky
2) pro uložení, zobrazení, analýzu všech historických parametrů křivky
3) může zobrazit všechny parametry dávkové sestavy
4) zkopírujte data přímo pomocí USB

5) data storage format is compatible with EXCEL, EXCEL platform can be to deal with
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Can the process control parameters, each parameter can have 10 block can be set
7. Lze nastavit zobrazení času každého intervalu záznamu parametrů
8. S nastavením obrazovky a kalibrací lze provést dva parametry

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. Each parameter of the transmission are independent modules, without disturbing each other, for easy maintenance
11.PH, DO and other parameters of control and associated controls can be adjusted

Konkurenční výhoda

Technický parametr:

Ne

Parameter

Směrnice

Funkce zpracování dat řídicí jednotky

1

PH

Zobrazovací rozsah: 0.00 ~ 14.00 ± 0.01

Auto-control range:2.00 ~ 12.00 ± 0.05

Fermentation kontrola procesu (According to the fermentation time, auto- control pH fluent, at least10 parts)

pH value historical and trend curve analysis

Kyselina, analýza alkalických dávkových křivek

Analýza formulářů šarže

Kyselina, záznam celkové dávky alkálií

Uchovávejte a doručujte data

2

DO

0-150±3%,zobrazení precision: 0.1%

It can be controlled by rev and feeding.

Fermentation kontrola procesu (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Analýza formulářů šarže

Uchovávejte a doručujte data

3

Odpěňovač

Automatický PID control and alarm

Fermentation kontrola procesu (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Záznam chybového stavu pěny

protipěnivý záznam celkové dávky

Analýza formulářů šarže

Uchovávejte a doručujte data

4

Rev

Automatický enactment a kontroly(50~300rpm±5‰)

Fermentation kontrola procesu (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Analýza formulářů šarže

Uchovávejte a doručujte data

5

teplota

Teplota chladicí vody: + 5-80± 0.2 ° C

Fermentation kontrola procesu (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Analýza formulářů šarže

Uchovávejte a doručujte data

6

Krmení

PID automatic enactment a kontroly

Fermentation kontrola procesu (According to the fermentation time, auto- control feeding fluent, at least10 parts)

Feeding value historical and trend curve analysis

Krmení záznamu celkové dávky

Analýza formulářů šarže

Uchovávejte a doručujte data

7

Tlak

Ruční ovládání, displej přístroje

8

Tok vzduchu

mass flowmeter control gas flow


Specifikace

System main parts

Položka

Produkt

Popis

Quant.

Zdroj

1

Nádrž

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom heating blanket.

1

Bailun

2

Machinery seal

John Crane

1

Velká Británie

3

Stirring motor

Mechanical stirring: TECO

1

TECO

4

Speed governor

Mechanical stirring: TECO

1

TECO

5

Silicon pipe

Lange

10M

Baoding

6

PLC system

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailun

7

Thermal mass flowmeter

10-100L/H Vogtlin

1

Švýcarsko

8

Air intake filter

Sartorius, 0.2μm Φ50

1

Sartorius

9

Filtr dýchání

Sartorius Φ37

1

Sartorius

10

Feeding peristaltic pump

BL-0~32 ml\min

1

Lange

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

Lange

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

Lange

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

Lange

14

PH electrode

Switzerland imported 225

1

Švýcarsko

15

PH cable

Switzerland imported 3m

1

Švýcarsko

16

DO electrode

Switzerland imported 220

1

Švýcarsko

17

DO cable

Switzerland imported 3m

1

Švýcarsko

18

Temperature electrode

PT100

1

Japonsko

19

Elektromagnetický ventil

DN8-UNIT

1

Tchaj-wan

20

jiní

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

Shanghai

Aplikace

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vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Biofaktorový bioreaktor
lékárna
farmaceutický průmysl
lékařství
Monoclonal antibodies
antibiotika
antibiotikum
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
Vakcína
Biopharmaceutical
lidské buňky
plant cell culture

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Copyright © 2016 Knik Technology Všechna práva vyhrazena.
Copyright 2016 Knik Technology Všechna práva vyhrazena