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Selbioreaktore-fermentors CGMP

5L 7L 10L 30L 40L sel bioreaktor (glas)

  • Beskrywing
  • Kompeterende voordeel
  • spesifikasies
  • aansoeke
  • ondersoek
Beskrywing

aantal

item

Beskrywing

2

Vessel system

Autoclavable bioreactor vessel,5L (3 - 3.5 liters working volume)    and  7 liter (4-5 liters working volume)  and  10 liter (5-7 liters working volume)total capacity

Lid Stainless steel 316L With sterile and pressure proof ports

bioreactor Vessel must be a Jacketed Vessel having with the head plate of SS316L. It should have the Temperature Control via circulation of Hot / Cold Water in the Jacket through an inbuilt Thermo circulator unit (working temperature range 8ºC - 80ºC above coolant temperature) The system must be complete to measure and control pH, DO, stirrer speed (20-300rpm), foam control & temperature.

Probes :   Impeller Speed, temperature, pH, redox, pO2, level or Foam, gas mixture

Gas Supplement : Air, O2, N2, CO2

geroer

Mechanical seal, shaft, 2 height adjustable six – blade stirrer, removable baffle cage

deurlugting

Auto cleavable sterile filter, check valve, connection piece, aeration tube with ring sparger

Required air pressure approx, 1.5 bar

ventilasie

Reflux cooler, connection piece, auto cleavable sterile filter

Temperature Circuit

Connected to glass double jackets, all four temperature circuits connected by central supply and drain lines.

probes

Autoclavable temperature probe Pt100 incl. connecting cable

Autoclavable pH-gel-electrode incl. connecting cable

Autoclavable pO2-probe incl. connecting cable

Autoclavable height adjustable antifoam-probe incl. connecting cable

Monsternemingstelsel

Autoclavable sampling system

Entstof

Cup for silicone diaphragm

Measurement of Controls

Integrated in stainless steel trunking

Kragtoevoer

Main power supply for all electrical circuits, 1 x 220V, 50 Hz

Temperatuur beheer

Including heating finger and cooling water valve in temperature circuit. Temperature controller for heating and cooling, temperature range 4-60C (depending on the available cooling media)

Spoedinstelling

DC motor with frequency converter, rpm-control unit

pH Control

pH-control to activate the dosage of acid and base (pumps)

pO2 Control

DDC pO2-control to activate the final elements, Cascade control vial stirrer speed and aeration valve

Antifoam Control

DDC antifoam - Control to activate the dosage to antifoam chemicals

Dosis

Aeration Unit

Consists of pressure valve, a rotameter (50-100L/h) a continuous solenoid valve (proportional valve), activated by pO2 controller, a check valve.

Peristaltic Pump with variable speed

2

Aeration system

Include rotameter, aeration filter

2

Agitation system

GJ:Meganiese verseëlingstelsel at the top of the fermenter; sterk krag stirring oar, antifoam oar; AC elektriese masjien:  infinite speed variation; rpm in the 5L germ fermenter: 20~300rpm±1%,The height of the stirring oar can be adjusted, too.

2

Temperatuurbeheer

Interlayer electric calefaction, auto-control

2

Airflow control

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2), Thermal mass flowmeter automatic control gas flow, valves, gas mix station to be included. Air filtration with membrane filter Supply capacity for fermenter: Air: upto 2 VVM, Oxygen 0.5 VVM, Sparger - One number sparger.

2

Beheermiddel teen skuim

Automatically check foam, automatically add antifoam by peristaltic pump.

2

Voerbeheer

Control by peristaltic pump switch, automatically feeding and computation.

2

pH control

Automatically add acid, alkali by peristaltic pump and control pH accurately.

2

DO control

Control with rotating speed relatively. 

1

BIO-S Biology process controller

Control parameter: temp, pH, DO, antifoam, stirrer rev, feeding; (Other parameters like glucose, amino acid, ethanol, oxygen, carbon dioxide, electric balance system can be chosen to use.)

Beheer stelsel

BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings.

10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system.

Software: Siemens S7+  FORCE  CONTORL

Data-insameling- en beheermodule: Siemens S200 PLC-beheerder en data-insameling- en beheermodule

1. beheer
① Manual control: You can set the percentage of open valve or a valve opening ② automatic control mode: You can select continuous or PID PID control the switch ③ sequence control: the control of all parameters can be pre-set at least 10 control section, ④ for automatic segmentation remotely control: PC control ⑤ acceptable correlation control: the dissolved oxygen can select speed, air flow rate, tank pressure, control of feeding, etc.; pH can choose to control with acid and alkali

 

2. Meting funksie: kan voed, borrel vyand, soos meting van pH
3. XY-axis to chart real progress can be any expansion and contraction of graphics display, to help the operator determine the parameters of the interaction between the effects of the fermentation process to quickly modify and adjust

4. Data verwerking
1) om aan te toon dat al die parameters van die tendenskurweanalise
2) om al die historiese kurwe-parameters op te slaan, te vertoon, te ontleed
3) kan al die parameters van die groepverslag vertoon
4) Kopieer die data direk met die USB

 

5) data stoor formaat is verenigbaar met EXCEL, EXCEL platform kan wees om te hanteer
5. Controller self-protection function: to set the password, others can not modify the fermentation parameters; and the controller is not lost due to power settings for each parameter
6. Kan die prosesbeheerparameters wees, kan elke parameter 10 blok bevat, kan ingestel word
7. Tydsvertoning van elke parameteropname-interval kan aangepas word
8. Twee parameters kan uitgevoer word met die skerminstellings en kalibrasie

9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display
10. Elke parameter van die transmissie is onafhanklike modules, sonder om mekaar te steur, vir maklike instandhouding
11. PH, DO en ander parameters van beheer en gepaardgaande kontroles kan aangepas word

Mededingende voordeel

Technical parameter:

 

Geen 

Parameter 

 

riglyn 

 

Controller data processing function 

1

PH

Displaying range: 0.00 ~ 14.00 ± 0.01 

Auto-control range:2.00 ~ 12.00 ± 0.05

Fermentasie proses beheer (According to the fermentation time, auto- control pH fluent, at least10 parts) 

pH value historical and trend curve analysis

Acid, alkali dosage curve analysis

Batch report form analysis

Acid, alkali total dosage record

Keep and deliver data

2

 

DO

 

0-150±3%,vertoon precision: 0.1%

It can be controlled by rev and feeding. 

Fermentasie proses beheer (According to the fermentation time, auto- control DO fluent, at least10 parts)

DO value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

3

 

 

antifoam

 

Outomatiese PID control and alarm 

Fermentasie proses beheer (According to the fermentation time, auto- control antifoam fluent, at least10 parts)

Antifoam value historical and trend curve analysis

Foam error state record 

antifoam total dosage record

Batch report form analysis

Keep and deliver data

4

 

 

Ds

Outomatiese verwerking en beheer(50~300rpm±5‰)

Fermentasie proses beheer (According to the fermentation time, auto- control rev fluent, at least10 parts)

Rev value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

5

 

temperatuur

Temperature of cooling water: +5-80± 0.2 ℃

Fermentasie proses beheer (According to the fermentation time, auto- control temperature fluent, at least10 parts)

Temperature value historical and trend curve analysis

Batch report form analysis

Keep and deliver data

6

 

 

Voeding

PID automatic verwerking en beheer 

Fermentasie proses beheer (According to the fermentation time, auto- control feeding fluent, at least10 parts) 

Feeding value historical and trend curve analysis

Feeding total dosage record

Batch report form analysis

Keep and deliver data

7

 

 

Druk

Manual control, instrument display 

 

8

 

 

Air flux

 mass flowmeter  control gas flow 

 


spesifikasies

System  main parts

item

Produk

Beskrywing

Hoeveelheid

Bron

1

tank

GJ, GC: stainless steel cover, Borosilicate glass tank, stainless steel round jacketed bottom and 5mm stainless steel jacketed tank, control temperature together, heating by bottom verwarmingskombers.

1

Bailun

2

Masjien seël

John Crane

1

Verenigde Koninkryk

3

Roer motor

Mechanical stirring: TECO     

1

TECO

4

Spoedbestuurder

Mechanical stirring: TECO     

1

TECO

5

Silicon pipe

Lange

10M

Baoding

6

PLS-stelsel

Germany Siemens S7-200 series PLC control system +10 inch Kunlun-type LCD touch screen + circuit control board + electrical boxes and various types of electrical appliances. Including cabinets, control core, signal acquisition, transmitter, power drive and other types of actuators

1

Bailun

7

Termiese massavloeimeter

10-100L/H    Vogtlin

1

Switserland

8

Air intake filter

Sartorius, 0.2μm φ50

1

Sartorius

9

Asemhalingsfilter

Sartorius φ37

1

Sartorius

10

Feeding peristaltic pump

BL-0~32 ml\min

1

Lange

11

Peristaltic pump(acid)

BL-0~28 ml\min

1

Lange

12

Peristaltic pump(Alkali)

BL-0~28 ml\min

1

Lange

13

Peristaltic pump(Defoaming)

BL-0~28 ml\min

1

Lange

14

PH  electrode

Switzerland imported 225

1

Switserland

15

PH cable

Switzerland imported 3m

1

Switserland

16

DO  electrode

Switzerland imported 220

1

Switserland

17

DO cable

Switzerland imported 3m

1

Switserland

18

Temperature  electrode

PT100

1

Japan

19

Elektromagnetiese klep

DN8-UNIT

1

Taiwan

20

ander

Feeding bottle, silicone tube, pipe, pipe rack, all kinds of valves, heaters, pressure gauges, bearings, seals, tools, etc.

1

Sjanghai

aansoeke
vaccine production plant
vaccine production line manufacturing
Pharmaceutical fermentation
Biopharmaceutical bioreactor
apteek 
farmaseutiese produkte
medisyne
Monoclonal antibodies
Antibiotika
antibiotika
Animal cells cultivation
animal cells suspension cultivation
veterinary medicine stirring tank
Entstof
biofarmaseutiese
human cells 
plant cell culture 
Kontak Ons

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