Biopharmaceutical Process Module GMP 2

2020 new bioreactor for COVID-19 vaccine

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The KNIKBIO-XV series fermentation tank is our company's unique equipment for bacterial vaccine cultivation: fully sealed, zero leakage, no pollution, and maintenance-free. The double mechanical seal completely solves the problem of bacterial contamination in the cultivation of biological product tanks. Various parameters in fermentation, such as pH, DO, temperature and stir speed can be monitored by the controller, and all data and control parameters can be transmitted to the controller or computer. The structure is compact, and various components can be integrated into the fermentation system. It can choose to adopt the direct coupling mechanical stirring mode driven by the upper motor or the indirect coupling mechanical stirring mode driven by the bottom magnetic force, with simple structure and stable operation.


Diameter to height ratio: 1:1~2.5; filling factor: 70%


Tank body: 316L stainless steel, easy to clean; stainless steel inner polishing accuracy Ra≤0.4;


Tank function: intake sterilization filter, exhaust condenser, including intake and exhaust treatment system, motor: special Sew AC motor for fermentation tank; double seal on the upper shaft end to ensure zero leakage


Ventilation: using multi-channel ventilation, thermal mass flow meter automatically controls air flow and oxygen flow


Pressure: Pressure control range: 0-0.3Mpa, pressure regulating valve adjusts the outlet pressure, digital remote transmission display.


Mixing system: Mixing form: straight and pitched blades (multi-stage)


Fermentation pH control function: intelligent PID control, Mettler PH electrode;


Fermentation dissolved oxygen control function: intelligent PID control, Mettler DO electrode;


Temperature control: intelligent PID control, electric heating, water cooling, circulating pump temperature control,


Feeding: complete feeding system (acid, alkali, antifoaming, culture agent)


Exhaust: exhaust after heating, filtering and inactivation.

Fermentation broth weighing system (optional): online detection of fermentation broth volume* (weight) with weighing Mettler sensor (Load cell).


Tank lid lifting system: automatically lift tank cover, easy to clean and maintain


SIP automatic sterilization system for tank and pipe: automatic program sterilization, reducing labor intensity and improving sterilization accuracy


CIP automatic cleaning system for tank (optional): automatic cleaning


KNIKBIO-D control system: Siemens S7-200 series PLC+12-inch tablet computer touch screen display, on-site direct operation (menu type), full English menu and interface; it can also transmit data to the host computer, sample and display tank data , Browse and analyze system data, read settings. Control or collect parameters such as pH, DO, tank pressure, temperature, rotation speed, air flow, feed weighing, fermentation broth volume, etc. The pH and DO electrodes can be easily calibrated through software; the initial control state of the set parameters; independent Curve analysis system; directly analyze historical curves

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